The Distribution, Diversity, and Control of Dirofilariosis in Brazil: A Comprehensive Review.

Simple Summary: Dirofilariosis, a zoonotic mosquito-borne disease, remains an under-studied condition in several areas of Brazil, despite its long-standing presence. This review aims to draw together prevalence data from epidemiological studies and case reports conducted in dogs over the last decade and in cats, wildlife, and humans over the last twenty years to define the distribution and prevalence of Dirofilaria spp. within the country and highlight the challenges associated with its diagnosis, treatment, and control. While Dirofilaria immitis is the main species circulating in Brazil, concerns have been raised in recent years about the presence of genetically distinct strains that may be more virulent than their Old World counterparts. In light of this and the widespread distribution of the parasite among both Brazilian coastal and non-coastal areas, further studies are required to characterise the disease. Additionally, there is a need to increase awareness of this neglected disease among health professionals in Brazil and to understand and minimise its impact on both veterinary and public health. Brazil's extensive coastline, tropical and subtropical climate, and well-preserved environment represent a conducive setting for dirofilariosis, a zoonotic mosquito-borne disease. Although this condition has long been recognised in the country, it has been relatively under-studied, and it is currently considered to be an emerging disease. Diagnosis, treatment, and control remain challenging due to the extensive gaps in knowledge. In order to help address this issue, this review aims to (i) summarise the available literature on the distribution of Dirofilaria spp. in Brazilian dogs over the last decade, (ii) review case reports of dirofilariosis in cats, wild animals, and humans over the last twenty years, and (iii) highlight the benefits of taking a One Health approach to managing this disease. While there have been several prevalence studies in dogs, disease distribution is poorly characterised in cats, and little is known about the occurrence of the parasite in wildlife. Human cases are sporadically reported, and no large-scale studies have been undertaken to date. Evidence indicates that Dirofilaria immitis is the main species circulating in Brazil, although Dirofilaria repens has also been detected. Molecular studies have also suggested the circulation of a highly virulent form of D. immitis, which may be genetically distinct from those of the Old World. A programme of epidemiological, ecological, genomic, and pathogenicity-based studies is required to quantify the impact of dirofilariosis in Brazil on both veterinary and public health and to inform others on its control. [ABSTRACT FROM AUTHOR]