Comprehensive analysis and probabilistic health risk assessment of antimicrobial residues in farmed shrimp from southeast China.

This study described the presence of twenty antimicrobial substances in farmed shrimp from southeast China and performed a probabilistic health risk assessment. Quinolones (QNs), tetracyclines (TCs), nitrofuran metabolites (NMs), chloramphenicols (CAPs), malachite green (MG), and leucomalachite green (LMG) were targeted for analysis in different shrimp species. The detection frequencies were 49.07 % for QNs, 33.39 % for NMs, 3.59 % for TCs, and 1.49 % for CAPs. It revealed high detectable levels of enrofloxacin, ciprofloxacin, and semicarbazide in shrimp samples. Detection frequencies varied among different shrimp species. Seasonal variations in residue concentrations were observed with higher levels detected in the summer months. The health risk assessment, conducted using Monte Carlo simulation, indicated that the estimated daily intake (EDI) of these substances was below the acceptable daily intake (ADI). It suggests there are minimal health risks to local consumers. However, the surveillance of antimicrobial substance residues in shrimp should be continuously conducted considering other potential hazards, such as antibiotic resistance and allergic reactions. • Antimicrobial substances were tested in shrimp with a large sample size (n=485). • Detection frequency was 49.07 % for quinolones, and 33.39 % for nitrofuran metabolites. • High levels of enrofloxacin, ciprofloxacin, and semicarbazide were found. • The detection frequencies of analytes were influenced by sampling months. • Enrofloxacin was the primary contributor to the targeted hazard quotients. [ABSTRACT FROM AUTHOR]