Synthesis of α-hydroxyketones via palladium-catalyzed arylation of arylglyoxals.

A palladium-catalyzed arylation reaction of arylglyoxals with arylboronic acids has been achieved. The reaction produces various acyclic α-hydroxyketones in high yields under mild conditions. Of merits mention, the rigorous exclusion of air and moisture is not required in these transformations, offering a straightforward and practical approach for the synthesis of α-hydroxyketones. [Display omitted] • A novel protocol synthesis of acyclic α-hydroxyketones. • The reaction conditions are mild and do not require inert or anhydrous conditions. • Easy operation and scale-up. [ABSTRACT FROM AUTHOR]