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Serum soluble alpha klotho and periostin as a biomarker for detection of early diabetic nephropathy in Iraqi male with Type 2 Diabetes.
- Source :
-
Journal of Research in Pharmacy . 2024, Vol. 28 Issue 5, p1665-1673. 9p. - Publication Year :
- 2024
-
Abstract
- Diabetic nephropathy (DN) is one of the most prevalent diabetic microvascular complications, affecting up to 40% of type 2 diabetic patients (T2DM) and represents a general reason of chronic kidney disorder and end-stage kidney disease (ESKD). This study aimed to evaluate the soluble alpha klotho and periostin (POSTN) role as predictor of diabetic-nephropathy (DN) on 120 patients, 60 with T2DM and 60 with DN under hemodialysis (DN-HD) in a crosssectional study. Serum-soluble alpha-klotho and periostin levels were evaluated using ELISA techniques. Receiver operating characteristic curves were used to evaluate the predictive value of soluble alpha-klotho and periostin, which revealed that soluble alpha-klotho significantly decreased in DN-HD patients compared to T2DM patients, while periostin significantly increased in DN-HD patients in comparison with T2DM patients. Specificity and sensitivity of the soluble alpha klotho in predicting DN were (62% and 59%), at cut-off value was 98.63 ng/mL, while periostin's sensitivity and specificity were (92% and 90%) at a cut-off value of 238.17 ng/mL which indicate that serum periostin can be considered as a valuable biomarker for early detection of DN in T2DM patients. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 26306344
- Volume :
- 28
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Journal of Research in Pharmacy
- Publication Type :
- Academic Journal
- Accession number :
- 179586829
- Full Text :
- https://doi.org/10.29228/jrp.842