CHARACTERIZATION, SYNTHESIS, AND BIOCOMPATIBILITY OF NiFe2O4/MoS2 2D NANOSHEETS/PEG EVALUATED THROUGH In-vitro ASSESSMENT OF ANTIPROLIFERATIVE, ANTIOXIDANT, AND ANTIBACTERIAL ACTIVITIES.

In this paper, cost-effective methods are used to synthesize NiFe2O4 nanoparticles-MoS2 nanosheets with double PEGylation (NIMPI). The preparation strategies were chosen to improve the characteristics and biocompatibility of nickel ferrite and dichalcogenide nanomaterials with polyethylene oxide polymer (PEG) at a low cost. Powder XRD, TEM, and XPS methods were used for structural and morphological research. This nanocomposite was synthesized to investigate the bio-efficacy of anticancer, antioxidant, and antibacterial properties. NIMPI was tested for antiproliferation efficacy in HepG-2 hepatocellular carcinoma (liver cancer) and MCF-7 adenocarcinoma (breast cancer) cell lines. Both HepG-2 along MCF-7 cell lines indicated high cytotoxic potential. SOD and H2O2 antioxidant assays were used to determine toxicity end-points. The strategy for attaining in vitro effectiveness and the key to understanding the unique interaction between PEGylation and ferrite nanoparticles encased in 2D MoS2 nanosheets are demonstrated in this study that gives a strong indication to assist the growth of antimicrobial, antioxidant, and cytotoxicity properties for major biomedical compatibility. [ABSTRACT FROM AUTHOR]