EFFECT OF MAGNESIUM SULPHATE ON INTUBATION AND INTRAOPERATIVE HEMODYNAMIC RESPONSE IN LAPROSCOPIC CHOLECYSTECTOMY.

Background: Endotracheal intubation and carbon dioxide pneumoperitoneum in patients undergoing laparoscopic cholecystectomy changes hemodynamic parameters. The impact of magnesium sulfate on hemodynamic responses during laparoscopic cholecystectomy remains controversial Objectives: To evaluate the efficacy of administration of magnesium sulphate to attenuate hemodynamic responses during laparoscopic cholecystectomy Methods: This was a randomized control study conducted in the department of Anaesthesia. Forty patients undergoing laparoscopic cholecystectomy were assigned into two groups. One group received magnesium sulfate (50mg/kg) and second group received normal saline (0.9%). Systolic and diastolic blood pressures, heart rate and mean arterial pressure were measured before the induction, at the end of infusion and after the induction in both the groups. Results: There is no statistically significant differences between magnesium sulphate and normal saline groups in terms of age, gender, weight, ASA grade and duration of surgery (p>0.05). Common adverse effects like bradycardia, and hypotension were observed. The mean values of systolic blood pressure, diastolic blood pressure, heart rate and mean arterial pressure were significantly less (P< 0.05) in magnesium sulphate group as compared to normal saline group. Conclusion: Magnesium sulphate effectively attenuates hemodynamic responses during intubation and pneumoperitoneum during laparoscopic cholecystectomy. [ABSTRACT FROM AUTHOR]