Study of Lactate, Lactate Albumin Ratio (LAR), Procalcitonin (PCT) and Immature Platelet Fraction (IPF) on admission in comparison to SOFA Score as a marker of severity in patients admitted with sepsis in tertiary care hospital.

AIM To assess the association of Lactate, Lactate Albumin Ratio, Procalcitonin and Immature Platelet Fraction in comparison to SOFA Score on admission as marker of severity in sepsis patients OBJECTIVES • To assess Lactate / Albumin Ratio (LAR) in patients with sepsis. • To assess Lactate value in patients with sepsis . • To assess Procalcitonin (PCT) value in patients with sepsis. • To assess Immature Platelet Function (IPF) value in patients with sepsis. • To compare Lactate, LAR, PCT and IPF with SOFA score on admission in patients with sepsis for prognostication MATERIAL AND METHODS • Hospital based Observational Cross-Sectional Study was conducted at Mahatma Gandhi Hospital, Jaipur between September 2022 to December 2023. Data of 180 patients was collected according to inclusion criteria. Sepsis biomarkers that is Lactate, LAR, IPF, PCT were calculated and were compared to SOFA score at the time of admission for the purpose of prognostication. RESULT These intra-group analyses underscore the nuanced interactions between biomarkers and organ dysfunction severity as assessed by SOFA scores in sepsis. While Procalcitonin demonstrated significant associations, highlighting their clinical relevance in stratifying disease severity, Lactate, Lacto-albumin ratio and IPF showed more variable associations. CONCLUSION In this study all four markers positively correlated with SOFA score, that is the level of markers increased along with severity of sepsis. But our study particularly identifies significant associations: SOFA scores correlate significantly with procalcitonin. The biomarkers of sepsis used in our study that is Lactate, Lactate Albumin Ratio (LAR), Immature Platelet Fraction (IPF), Procalcitonin (PCT) can be used to enhance early risk stratification and guide more tailored therapeutic interventions for septic patients. [ABSTRACT FROM AUTHOR]