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Comparative studies on substrate specificity of succinic semialdehyde reductase from Gluconobacter oxydans and glyoxylate reductase from Acetobacter aceti.
- Source :
-
Bioscience, Biotechnology & Biochemistry . Sep2024, Vol. 88 Issue 9, p1069-1072. 4p. - Publication Year :
- 2024
-
Abstract
- Gluconobacter oxydans succinic semialdehyde reductase (GoxSSAR) and Acetobacter aceti glyoxylate reductase (AacGR) represent a novel class in the β-hydroxyacid dehydrogenases superfamily. Kinetic analyses revealed GoxSSAR's activity with both glyoxylate and succinic semialdehyde, while AacGR is glyoxylate specific. GoxSSAR K167A lost activity with succinic semialdehyde but retained some with glyoxylate, whereas AacGR K175A lost activity. These findings elucidate differences between these homologous enzymes. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ACETOBACTER
*BIOCHEMICAL substrates
*DEHYDROGENASES
*COMPARATIVE studies
*ENZYMES
Subjects
Details
- Language :
- English
- ISSN :
- 09168451
- Volume :
- 88
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Bioscience, Biotechnology & Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 179513077
- Full Text :
- https://doi.org/10.1093/bbb/zbae081