Prospecting for para-endogenous anxiolytics in the human microbiome: Some promising pathways.

The gut microbiome is a vast, variable, and largely unexplored component of human biology that sits at the intersection of heritable and environmental factors, and represents a rich source of novel chemistry that is already known to be compatible with the human body. This alone would make it a promising place to search for new therapeutics, but recent work has also identified gut microbiome abnormalities in patients with a number of psychiatric disorders, including anxiety disorders—suggesting that not only treatments, but cures may lie therein. Here, we'll discuss two known "para-endogenous" anxiolytics—γ-hydroxybutyrate and the neurosteroid allopregnanolone—which have recently been discovered to be produced by the microbiome. • Many human-gut-native bacteria are known to produce anxiolytic compounds. • Known examples include the pregnanolone neurosteroids and the GABA derivative GHB. • Dysbiosis might lead to a deficiency of these and similar metabolites • Loss of para-endogenous anxiolytics may play a role in anxiety & related disorders. • Restoring anxiolytic microbes may represent not just a treatment, but a cure. [ABSTRACT FROM AUTHOR]