Paediatric acute lymphoblastic leukaemia‐associated haemophagocytic lymphohistiocytosis develops during prednisolone prephase.

This document is a letter to the editor discussing a study on pediatric acute lymphoblastic leukemia (ALL)-associated hemophagocytic lymphohistiocytosis (HLH). The study found that liver enzymes and activated CD8+ T cells were increased in patients with ALL-associated HLH. The authors suggest that liver enzyme elevations could serve as diagnostic markers for this potentially fatal disease. The study has some limitations, including its retrospective design and the unavailability of laboratory data for some patients in the control group. Further investigation is needed to understand the incidence and clinical characteristics of ML-HLH associated with pediatric ALL. [Extracted from the article]