Design, Synthesis, Anticancer Evaluation and Molecular Docking Studies of Amide Derivatives of Thienopyrimidine Isoxazoles.

This article discusses the design, synthesis, and evaluation of amide derivatives of thienopyrimidine isoxazoles for their anticancer properties. The researchers synthesized a library of compounds and tested their anticancer activities against four different cancer cell lines. Two compounds, 13a and 13e, showed particularly promising results. Molecular docking analysis revealed the key interactions of the compounds with the target protein, ATR kinase. The document also describes the synthesis, characterization, and cytotoxic activity testing of several other compounds, as well as the methods used for molecular docking studies. The study was financially supported by the Deanship of Scientific Research, King Khalid University, and no conflicts of interest were reported by the authors. [Extracted from the article]