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Fluoroamphiphilic polymers exterminate multidrug-resistant Gram-negative ESKAPE pathogens while attenuating drug resistance.

Authors :
Qian Zhou
Kunpeng Li
Kun Wang
Weilin Hong
Jingjie Chen
Jin Chai
Luofeng Yu
Zhangyong Si
Peng Li
Source :
Science Advances. 8/30/2024, Vol. 10 Issue 35, p1-11. 11p.
Publication Year :
2024

Abstract

ESKAPE pathogens are a panel of most recalcitrant bacteria that could "escape" the treatment of antibiotics and exhibit high incidence of drug resistance. The emergence of multidrug-resistant (MDR) ESKAPE pathogens (particularly Gram-negative bacteria) accounts for high risk of mortality and increased resource utilization in health care. Worse still, there has been no new class of antibiotics approved for exterminating the Gram-negative bacteria for more than 50 years. Therefore, it is urgent to develop novel antibacterial agents with low resistance and potent killing efficacy against Gram-negative ESKAPE pathogens. Herein, we present a class of fluoropolymers by mimicking the amphiphilicity of cationic antimicrobial peptides. Our optimal fluoroamphiphilic polymer (PD45HF5) displayed selective antimicrobial ability for all MDR Gram-negative ESAKPE pathogens, low resistance, high in vitro cell selectivity, and in vivo curative efficacy. These findings implied great potential of fluoroamphiphilic cationic polymers as promising antibacterial agents against MDR Gram-negative ESKAPE bacteria and alleviating antibiotic resistance. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
23752548
Volume :
10
Issue :
35
Database :
Academic Search Index
Journal :
Science Advances
Publication Type :
Academic Journal
Accession number :
179455951
Full Text :
https://doi.org/10.1126/sciadv.adp6604