Star anise (Illicium verum Hook. F.) polysaccharides: Potential therapeutic management for obesity, hypertension, and diabetes.

This study explores the extraction of polysaccharides from star anise (Illicium verum Hook. f.) with its anti-obesity, antihypertensive, antidiabetic, and antioxidant properties. The aim is to optimize the extraction conditions of star anise polysaccharides (SAP) utilizing propane alcohols-based deep eutectic solvents and microwave-assisted methods. The optimized conditions resulted in an extraction yield of 5.14%. The characteristics of acidic pectin-like SAP, including high viscosity (44.86 mPa s), high oil-holding capacity (14.39%), a high degree of esterification (72.53%), gel-like properties, highly amorphous, a high galacturonic acid concentration, and a highly branching size polysaccharide structure, significantly contribute to their potent inhibition of pancreatic lipase (86.67%), angiotensin-converting enzyme (73.47%), and α-glucosidase (82.33%) activities as well as to their antioxidant properties of azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS, 34.94%) and ferric ion reducing antioxidant power (FRAP, 0.56 mM FeSO 4). Therefore, SAP could be used as a potential therapeutic agent for obesity, hypertension, and diabetes mellitus management. [Display omitted] • SAP was successfully extracted using the microwave-DES assisted extraction method. • Parameters of SAP extraction via microwave-DES assistance were optimized using BBD. • Acidic pectin-like polysaccharides were extracted from star anise. • SAP: Potent anti-obesity, antihypertensive, antidiabetic, and antioxidant agents. • SAP: High OHC, viscosity, and complex branched polysaccharide structure. [ABSTRACT FROM AUTHOR]