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Polyoxometalate‐Polymer Directed Macromolecular Architectonics of Silver Nanoparticles as Effective Antimicrobials.

Polyoxometalate‐Polymer Directed Macromolecular Architectonics of Silver Nanoparticles as Effective Antimicrobials.

Authors :
Datta, Lakshmi Priya
Dutta, Debanjan
Mukherjee, Riya
Das, Tapan Kumar
Biswas, Subharanjan
Source :
Chemistry - An Asian Journal. 9/2/2024, Vol. 19 Issue 17, p1-7. 7p.
Publication Year :
2024

Abstract

A novel inorganic‐organic‐inorganic ternary bioactive material formulated on antimicrobial peptide‐based polymer has been reported. Supramolecular approach has been employed to incorporate molecularly crowded tyrosine‐based polymer stabilized silver nanoparticles into membrane bound vesicles exploiting polyoxometalate‐triggered surface templating strategy. Utilizing the covalent reversible addition fragmentation chain transfer (RAFT) polymerization and exploiting templated supramolecular architectonics at biopolymer interface, the bioactive ternary polymeric nanohybrids have been designed against Shigellosis leveraging the antibacterial activities of silver nanoparticle, cationic amphiphilic tyrosine polymer and inorganic polyoxometalate. The detail investigation against Shigella flexneri 2a cell line demonstrates that the collaborative mechanism of the ternary hybrid composite enhances the bactericidal activity in comparison to only polyoxometalate and polymer stabilized silver nanoparticle with an altered mechanism of action which is established via detailed biological analysis. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
18614728
Volume :
19
Issue :
17
Database :
Academic Search Index
Journal :
Chemistry - An Asian Journal
Publication Type :
Academic Journal
Accession number :
179411879
Full Text :
https://doi.org/10.1002/asia.202400344