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Metabolic Patterns of Fluconazole Resistant and Susceptible Candida auris Clade V and I.

Authors :
Barough, Robab Ebrahimi
Javidnia, Javad
Davoodi, Ali
Talebpour Amiri, Fereshteh
Moazeni, Maryam
Sarvi, Shahabeddin
Valadan, Reza
Siahposht-Khachaki, Ali
Moosazadeh, Mahmood
Nosratabadi, Mohsen
Haghani, Iman
Meis, Jacques F.
Abastabar, Mahdi
Badali, Hamid
Source :
Journal of Fungi. Aug2024, Vol. 10 Issue 8, p518. 9p.
Publication Year :
2024

Abstract

Candida auris, an emerging non-albicans multidrug-resistant yeast, has become a significant cause of invasive candidiasis in healthcare settings. So far, data on the metabolites of C. auris in different clades are minimal, and no studies have focused on clade V metabolites. Therefore, Gas chromatography–mass spectrometry (GC-MS) was used for the metabolomic profiling of clade I C. auris compared with fluconazole-resistant and susceptible C. auris in clade V strains. GC-MS chromatography revealed 28, 22, and 30 compounds in methanolic extracts of the fluconazole-susceptible and fluconazole-resistant C. auris clade V and C. auris clade I strain, respectively. Some compounds, such as acetamide and metaraminol, were found in fluconazole-susceptible and resistant C. auris clade V and clade I. N-methyl-ethanamine and bis(2-ethylhexyl) phthalate metabolites were found in both fluconazole -susceptible and resistant C. auris clade V, as well as 3-methyl-4-isopropylphenol, 3,5-bis(1,1-dimethyl)-1,2-benzenediol, and diisostyl phthalate metabolites in both fluconazole resistant C. auris clade V and I. Identifying these metabolites contributes to understanding the morphogenesis and pathogenesis of C. auris, highlighting their potential role in antifungal drug resistance and the control of fungal growth. However, further experiments are warranted to fully comprehend the identified metabolites' regulatory responses, and there may be potential challenges in translating these findings into clinical applications. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
2309608X
Volume :
10
Issue :
8
Database :
Academic Search Index
Journal :
Journal of Fungi
Publication Type :
Academic Journal
Accession number :
179381346
Full Text :
https://doi.org/10.3390/jof10080518