Epithelial misplacement in Peutz–Jeghers polyps—the efficacy of the distribution of immunohistochemical markers in its diagnosis.

This article discusses the diagnostic difficulties associated with epithelial misplacement in Peutz-Jeghers polyps, a rare autosomal dominant gastrointestinal polyposis syndrome. The polyps are characterized by well-organized arborising muscular fibers lined by normal or hyperplastic mucosa. Epithelial misplacement, particularly in the small intestine, can mimic well-differentiated adenocarcinoma, leading to misdiagnosis. The article explores the use of immunohistochemical markers in differentiating non-neoplastic epithelium from neoplastic epithelium and emphasizes the importance of accurate diagnosis to prevent over-treatment. [Extracted from the article]