Biofilm formation and microbial interactions in moving bed-biofilm reactors treating wastewater containing pharmaceuticals and personal care products: A review.

The risk of pharmaceuticals and personal care products (PPCPs) has been paid more attention after the outbreak of COVID-19, threatening the ecology and human health resulted from the massive use of drugs and disinfectants. Wastewater treatment plants are considered the final stop to restrict PPCPs from wide spreading into the environment, but the performance of conventional treatment is limited due to their concentrations and characteristics. Previous studies have shown the unreplaceable capability of moving bed-biofilm reactor (MBBR) as a cost-effective method with layered microbial structure for treating wastewater even with toxic compounds. The biofilm community and microbial interactions are essential for the MBBR process in completely degrading or converting types of PPCPs to secondary metabolites, which still need further investigation. This review starts with discussing the initiation of MBBR formation and its influencing parameters according to the research on MBBRs in the recent years. Then the efficiency of MBBRs and the response of biofilm after exposure to PPCPs are further addressed, followed by the bottlenecks proposed in this field. Some critical approaches are also recommended for mitigating the deficiencies of MBBRs based on the recently published publications to reduce the environmental risk of PPCPs. Finally, this review provides fundamental information on PPCPs removal by MBBRs with the main focus on microbial interactions, promoting the MBBRs to practical application in the real world of wastewater treatment. [Display omitted] • Biofilm formation and characteristics were vital to the conventional nutrient and PPCPs removal in MBBRs. • Crucial parameters for biofilm formation and the removal of PPCPs were carefully discussed. • The microbial response of MBBR under the stress of PPCPs was investigated. • Coupled systems with MBBRs and other physiochemical methods were the new trend for enhancing PPCPs removal. • Further research should be conducted on the regulatory rules by QS for microbial interactions. [ABSTRACT FROM AUTHOR]