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Genetic determinants of coping, resilience and self-esteem in schizophrenia suggest a primary role for social factors and hippocampal neurogenesis.

Authors :
Mazzarotto, Francesco
Monteleone, Palmiero
Minelli, Alessandra
Mattevi, Stefania
Cascino, Giammarco
Rocca, Paola
Rossi, Alessandro
Bertolino, Alessandro
Aguglia, Eugenio
Altamura, Carlo
Amore, Mario
Bellomo, Antonello
Bucci, Paola
Collantoni, Enrico
Dell'Osso, Liliana
Di Fabio, Fabio
Fagiolini, Andrea
Giuliani, Luigi
Marchesi, Carlo
Martinotti, Giovanni
Source :
Psychiatry Research. Oct2024, Vol. 340, pN.PAG-N.PAG. 1p.
Publication Year :
2024

Abstract

• Resilience, coping and self-esteem are outcome predictors in schizophrenia (SCZ). • A GWAS on 490 SCZ patients characterized with 4 dedicated scales was performed. • Sixteen loci emerge as (at least suggestively) associated with these scales. • There is genetic overlap with SCZ itself, neuroticism and worry. • Social-, hippocampal- and lipid-related aspects appear generally relevant. Schizophrenia is a severe psychiatric disorder, associated with a reduction in life expectancy of 15–20 years. Available treatments are at least partially effective in most affected individuals, and personal resources such as resilience (successful adaptation despite adversity) and coping abilities (strategies used to deal with stressful or threatening situations), are important determinants of disease outcomes and long-term sustained recovery. Published findings support the existence of a genetic background underlying resilience and coping, with variable heritability estimates. However, genome-wide analyses concerning the genetic determinants of these personal resources, especially in the context of schizophrenia, are lacking. Here, we performed a genome-wide association study coupled with accessory analyses to investigate potential genetic determinants of resilience, coping and self-esteem in 490 schizophrenia patients. Results revealed a complex genetic background partly overlapping with that of neuroticism, worry and schizophrenia itself and support the importance of social aspects in shapingthese psychological constructs. Hippocampal neurogenesis and lipid metabolism appear to be potentially relevant biological underpinnings, and specific miRNAs such as miR-124 and miR-137 may warrant further studies as potential biomarkers. In conclusion, this study represents an important first step in the identification of genetic and biological correlates shaping resilience, coping resources and self-esteem in schizophrenia. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
01651781
Volume :
340
Database :
Academic Search Index
Journal :
Psychiatry Research
Publication Type :
Academic Journal
Accession number :
179364377
Full Text :
https://doi.org/10.1016/j.psychres.2024.116107