Closed-Loop Transcranial Alternating Current Stimulation for the Treatment of Major Depressive Disorder: An Open-Label Pilot Study.

This article presents the findings of a pilot study on the use of closed-loop transcranial alternating current stimulation (CL-tACS) for the treatment of major depressive disorder (MDD). The study focused on stimulating alpha oscillations in the prefrontal cortex, which are associated with depression symptoms. The results showed that CL-tACS significantly reduced depression severity and improved quality of life in participants. A subsequent clinical trial found that CL-tACS had an 80% response rate and an 80% remission rate two weeks after treatment. EEG results also showed a decrease in symptom severity. The study suggests that CL-tACS could be a safe and effective non-pharmacological treatment option for MDD. [Extracted from the article]