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N-(2-Carboxyphenyl)oxalamides in the synthesis of the quinazoline central nervous system depressant methaqualone and fused biheterocyclic systems.

Authors :
Mamedova, V. L.
Kushatov, T. A.
Tikhomirova, N. A.
Sinyashin, O. G.
Mamedov, V. A.
Source :
Russian Chemical Bulletin. Jul2024, Vol. 73 Issue 7, p1996-2003. 8p.
Publication Year :
2024

Abstract

A synthesis of the quinazolin-4-one pharmacological agent methaqualone from N-(2-carboxyphenyl)oxalamide was developed. A new method for the reductive cyclization of 3-(2-nitrophenyl)quinazolin-4-ones to benzimidazo[2,1-b]quinazolin-12(6H)-ones, the 6-deoxo-6-aza analogs of natural alkaloid tryptanthrine, was suggested and new derivatives of poorly available quinoxalinoquinazolinone fused system were synthesized. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
10665285
Volume :
73
Issue :
7
Database :
Academic Search Index
Journal :
Russian Chemical Bulletin
Publication Type :
Academic Journal
Accession number :
179358387
Full Text :
https://doi.org/10.1007/s11172-024-4319-2