Study on the adsorption of Andrographolide by metal organic framework MIL-101.

MIL-101 (Cr) Was synthesized by hydrothermal method, and its phase structure and micro- structure were characterized by PXRD and SEM, resulting in a BET of 2 800 m²/g of MIL-101 adsorbent. The static adsorption experiment showed that MIL-101 had saturated mass adsorption rate of 8.36% and 7.05% for Andrographolide and dehydrated Andrographolide in a 60% methanol aqueous solution, respectively; MIL-101 was loaded onto chromatographic silica gel to prepare a chromatographic column (4.6 mm x 250 mm), and its penetration curves for two types of lactones and online separation performance for lactone mixtures were measured. The results showed that the experimental prepared chromatographic column had a separation degree of 1.9 for Andrographolide and dehydrated Andrographolide, with a separation efficiency of >99%, achieving online efficient separation. [ABSTRACT FROM AUTHOR]