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Halochromic Bacterial Cellulose/Anthocyanins Hybrid Polymer Film with Wound-Healing Potential.

Authors :
Zubova, Ganna
Melnyk, Hanna
Zaets, Iryna
Sergeyeva, Tetyana
Havryliuk, Olesia
Rogalsky, Sergiy
Khirunenko, Lyudmila
Zaika, Leonid
Ruban, Tetiana
Antonenko, Svitlana
Kozyrovska, Natalia
Source :
Polymers (20734360). Aug2024, Vol. 16 Issue 16, p2327. 20p.
Publication Year :
2024

Abstract

Polymer-based dressings deriving from natural biomaterials have advantages such as nontoxicity, biocompatibility, and mechanical stability, which are essential for efficient wound healing and microbial infection diagnostics. Here, we designed a prototype of an intelligent hydrogel dressing on the base of bacterial cellulose (BC) for monitoring wound microbial infection due to the uploaded natural pH dye-sensor, anthocyanins (ANC) of elderberry fruit (Sambucus nigra L.). The highest sensor responses to bacterial metabolites for ANC immobilized to BC were observed at pH 5.0 and 6.0. The detection limit of the sensor signals was 3.45 A.U., as it was evaluated with a smartphone-installed application. The FTIR spectral analysis of the hybrid BC/ANC hydrogel films has proved the presence of anthocyanins within the BC matrix. Hybrid films differed from the control ones by thicker microfibrils and larger pores, as detected with scanning electron microscopy. Halochromic BC/ANC films exhibited antimicrobial activities mainly against gram-positive bacteria and yeast. They showed no cytotoxicity for the in vitro human cell lines and mouse fibroblasts within a selected range of anthocyanin concentrations released from the BC/ANC film/dressing prototype. Compared to the control, the in vitro healing test showed overgrowth of primary mouse fibroblasts after applying 0.024–2.4 µg/mL ANC. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20734360
Volume :
16
Issue :
16
Database :
Academic Search Index
Journal :
Polymers (20734360)
Publication Type :
Academic Journal
Accession number :
179354525
Full Text :
https://doi.org/10.3390/polym16162327