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Advancements in the study of glucose metabolism in relation to tumor progression and treatment.

Authors :
Zhao, Meng
Chen, Yu-long
Yang, Lian-He
Source :
Progress in Biophysics & Molecular Biology. Oct2024, Vol. 192, p11-18. 8p.
Publication Year :
2024

Abstract

Sugar serves as the primary energy source for mammals, with glucose metabolism facilitating energy acquisition in human cells. The proper functioning of intracellular glucose metabolism is essential for the maintenance of orderly and healthy physiological activities. Tumor cells, characterized by uncontrolled growth, exhibit dysregulated proliferation and apoptosis processes, leading to abnormal alterations in glucose metabolism. Specifically, tumor cells exhibit a shift towards aerobic glycolysis, resulting in the production of lactic acid that can be utilized as a metabolic intermediate for sustained tumor cell growth. This article provides a comprehensive overview of the enzymes involved in glucose metabolism and the alterations in gene expression that occur during tumor progression. It also examines the current research on targeting abnormal glucose metabolism processes for tumor treatment and discusses potential future directions for utilizing glucose metabolism as a therapeutic target. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00796107
Volume :
192
Database :
Academic Search Index
Journal :
Progress in Biophysics & Molecular Biology
Publication Type :
Academic Journal
Accession number :
179321960
Full Text :
https://doi.org/10.1016/j.pbiomolbio.2024.08.001