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Neuronal AMPK regulates lipid transport to microglia.
- Source :
-
Trends in Cell Biology . Sep2024, Vol. 34 Issue 9, p695-697. 3p. - Publication Year :
- 2024
-
Abstract
- In neurodegeneration, neurons release lipids that accumulate in glial lipid droplets (LDs). But what controls lipid transport and how does this affect glia? A recent study by Li et al. discovered that the loss of neuronal AMP-activated protein kinase (AMPK) activity promotes lipid efflux, which drives a proinflammatory state in microglia. [ABSTRACT FROM AUTHOR]
- Subjects :
- *AMP-activated protein kinases
*PROTEIN kinases
*INFLAMMATION
*MICROGLIA
*LIPIDS
Subjects
Details
- Language :
- English
- ISSN :
- 09628924
- Volume :
- 34
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Trends in Cell Biology
- Publication Type :
- Academic Journal
- Accession number :
- 179262288
- Full Text :
- https://doi.org/10.1016/j.tcb.2024.08.001