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Effectiveness of high‐dose esomeprazole or pantoprazole 10‐day sequential therapy empirically prescribed in Helicobacter pylori‐infected naïve patients: a retrospective study.

Authors :
Pavoni, Matteo
Fiorini, Giulia
Zullo, Angelo
Saracino, Ilaria Maria
Gatta, Luigi
Manta, Raffaele
Imbrogno, Andrea
Lazzarotto, Tiziana
Borghi, Claudio
Vaira, Dino
Source :
Journal of Gastroenterology & Hepatology. Aug2024, p1. 5p. 1 Illustration.
Publication Year :
2024

Abstract

Background and Aim Methods Results Conclusions Helicobacter pylori infection is one of the most common bacterial infections affecting humans, causing gastroduodenal and extraintestinal diseases. Treatment of the infection remains challenging for the clinicians, and different factors are involved in the failure of the therapeutic approach. The importance of the intensity of acid secretion inhibition remains an unclear issue. The aim of this study is to assess whether 80 mg/day esomeprazole‐based 10‐day sequential therapy (esomeprazole‐ST) achieved different eradication rates when compared to 80 mg/day pantoprazole‐based analogous regimen (pantoprazole‐ST).This was a retrospective observational study where data of consecutive patients referred by their physicians to our unit to perform an upper gastrointestinal endoscopy were analyzed.Overall, 1,327 patients were available for the analysis: 599 and 728 patients received pantoprazole‐ST and esomeprazole‐ST, respectively. Eradication rate was significantly higher in patients receiving esomeprazole‐ST (92.6%, 95% CI: 91–94.5) than pantoprazole‐ST (89.3%, 95% CI: 86.7–91.7; difference: 3.3%; 95% CI: 0.2–6.5; <italic>P</italic> = 0.037). Even after a multivariate analysis, the esomeprazole‐ST achieved a significantly higher eradiation (OR: 1.44; 95% CI: 1.1–2.17).This study showed that esomeprazole‐ST achieved significantly higher H. pylori cure rates than pantoprazole‐ST. Prospective and well‐designed trials are demander to confirm this prelaminar finding. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
08159319
Database :
Academic Search Index
Journal :
Journal of Gastroenterology & Hepatology
Publication Type :
Academic Journal
Accession number :
179252855
Full Text :
https://doi.org/10.1111/jgh.16731