Two Cationic Indole Alkaloids from Ophiorrhiza japonica and Their Xanthine Oxidase Inhibitory Activity.

Two previously undescribed cationic indole alkaloids, named ophiorrhines L (1) and M (2), was isolated from the Ophiorrhiza japonica. The structures were elucidated based on spectroscopic data and quantum calculations as well as X-ray crystallographic analysis. Alkaloids 1 and 2 exhibited moderate inhibitory activities on XOD (Xanthine Oxidase) with IC50 values 42.5 and 22.6 μM, respectively. [ABSTRACT FROM AUTHOR]