Engineering metal-organic frameworks-based nanozymes for enhanced biomimetic catalytic sensing.

Nanozymes have been viewed a kind of emerging nanomaterials with enzyme-mimicking catalytic activity, which have the advantage of low cost and good robustness. However, the complex nano-effect and surface interface effect of nanozymes hinder the in-depth understanding of their enzyme-like catalytic activities and the development of highly active nanozymes to some extent. To date, metal-organic frameworks (MOFs)-based nanozymes have been widely exploited due to the unique structural characteristics and customizability, which can mimic the active center and hydrophobic domain of natural enzymes, providing great opportunities in rationally developing MOFs with enhanced catalytic activity. Herein, we systematically summarize the activity regulatory strategies of MOFs-based nanozymes and their applications in biosensing. Firstly, the engineering design strategies containing modulation of metal node, ligand, defect, morphology, and topology are introduced. Then, the distinctive applications of MOFs-based nanozymes in biosensing are also discussed. At the end, the recent challenges and progressive directions are tentatively proposed. [Display omitted] • Engineering MOFs-based nanozymes for enhanced biosensing. • The de novo design of MOFs-based nanozymes. • Activity regulatory strategies of MOFs-based nanozymes. • The current challenges and future prospects of MOFs-based nanozymes. [ABSTRACT FROM AUTHOR]