开颅手术引发颅内感染的危险因素及临床治疗效果分析.

Objective: To investigate the risk factors of intracranial infection caused by craniotomy and the clinical therapeutic effect. Methods: The case data of 661 patients who underwent craniotomy in our hospital from January 2018 to December 2022 were retrospectively selected. Clinical data of patients undergoing craniotomy were collected to determine the occurrence of intracranial infection caused by craniotomy. The risk factors of intracranial infection after craniotomy were determined by univariate and binary Logistic retrospective analysis. To analyze the distribution and composition of pathogenic bacteria in intracranial infected patients and the therapeutic effect of intracranial infected patients after craniotomy. Results: The incidence of postoperative intracranial infection was 5.75% in 661 patients with craniotomy. Among 38 patients with intracranial infection after craniotomy, there were 30 cases of gram-positive bacteria, accounting for 81.58% (31/38), 8 cases of gram-negative bacteria, accounting for 18.42%(7/38), and staphylococcus, accounting for 78.95%(30/38), accounted for the largest proportion. The protective factors were preoperative prophylactic antibiotics, and the risk factors were operative time 4 h, albumin level 36 g/L, postoperative cerebrospinal fluid leakage, indwelling drainage tube, and infratentorial surgery(P<0.05). Among the 38 patients, 33 were cured and 5 had no clinical symptoms at discharge. All patients were followed up by outpatient or telephone for 3-6 months after discharge, and there was no recurrence of inflammation. Conclusion: After craniotomy postoperative incidence of intracranial infection is 5.75%, protective factors for preoperative prophylactic antibiotics, risk factors for operation time 4 h, albumin level 36 g/L, postoperative cerebrospinal fluid leakage, indwelling drainage tube, screen operation, craniotomy postoperative intracranial infection accounted for the most, by giving active treatment, for confirmed craniotomy postoperative intracranial patients infection, early diagnosis and give sufficient amount of sensitive antibiotics treatment. [ABSTRACT FROM AUTHOR]