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Aging in chronic lung disease: Will anti-aging therapy be the key to the cure?

Authors :
Wang, Weijie
Zhou, Kai
Wang, Leyuan
Qin, Qiuyan
Liu, Huijun
Qin, Ling
Yang, Ming
Yuan, Lin
Liu, Chi
Source :
European Journal of Pharmacology. Oct2024, Vol. 980, pN.PAG-N.PAG. 1p.
Publication Year :
2024

Abstract

Chronic lung disease is the third leading cause of death globally, imposing huge burden of death, disability and healthcare costs. However, traditional pharmacotherapy has relatively limited effects in improving the cure rate and reducing the mortality of chronic lung disease. Thus, new treatments are urgently needed for the prevention and treatment of chronic lung disease. It is particularly noteworthy that, multiple aging-related phenotypes were involved in the occurrence and development of chronic lung disease, such as blocked proliferation, telomere attrition, mitochondrial dysfunction, epigenetic alterations, altered nutrient perception, stem cell exhaustion, chronic inflammation, etc. Consequently, senescent cells induce a series of pathological changes in the lung, such as immune dysfunction, airway remodeling, oxidative stress and regenerative dysfunction, which is a critical issue that needs special attention in chronic lung diseases. Therefore, anti-aging interventions may bring new insights into the treatment of chronic lung diseases. In this review, we elaborate the involvement of aging in chronic lung disease and further discuss the application and prospects of anti-aging therapy. • Aging is one of the contributing factors to the development of chronic lung diseases. • Aging contributes to the formation of various pathological phenotypes in chronic lung diseases. • Anti-Aging drugs show promising prospects in the treatment of chronic lung diseases. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00142999
Volume :
980
Database :
Academic Search Index
Journal :
European Journal of Pharmacology
Publication Type :
Academic Journal
Accession number :
179170946
Full Text :
https://doi.org/10.1016/j.ejphar.2024.176846