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Oncogenic roles of long non-coding RNAs in essential glioblastoma signaling pathways.

Authors :
Lashkarboloki, Mina
Jahanbakhshi, Amin
Mowla, Seyed Javad
Bjeije, Hassan
M. Soltani, Bahram
Source :
Journal of Neurogenetics. Aug2024, p1-17. 17p. 3 Illustrations.
Publication Year :
2024

Abstract

AbstractGlioblastoma multiforme (GBM) is an aggressive and diffuse type of glioma with the lowest survival rate in patients. The recent failure of multiple treatments suggests that targeting several targets at once may be a different strategy to overcome GBM carcinogenesis. Normal function of oncogenes and tumor suppressor genes need for the preservation of regular cellular processes, so any defects in these genes’ activity, operate the corresponding signaling pathways, which initiate carcinogenic processes. Long non-coding RNAs (lncRNAs) that can be found in the cytoplasm or nucleus of the cells, control the transcription and translation of genes. LncRNAs perform a variety of functions, including epigenetic alteration, protein modification and stability, transcriptional regulation, and competition for miRNA that regulate mRNA translation through sponging miRNAs. Identification of various oncogenic lncRNAs and their multiple roles in brain cancers making them potential candidates for use as glioma diagnostic, prognostic, and therapeutic targets in the future. This study highlighted multiple oncogenic lncRNAs and classified them into different signaling pathways based on the regulated target genes in glioblastoma. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
01677063
Database :
Academic Search Index
Journal :
Journal of Neurogenetics
Publication Type :
Academic Journal
Accession number :
179155348
Full Text :
https://doi.org/10.1080/01677063.2024.2390403