Fabrication and characterization of TiO2‐hydroxyapatite composite‐loaded Polysulfone membranes with integrated biocompatibility for dialysis application.

Background: The use of Polysulfone (PSf) as membrane material for dialysis therapy is becoming more common. However, the PSf membrane can cause the adsorption of blood proteins followed by the adhesion of platelets, destruction of red blood cells, and thrombus formation. One of the biggest challenges in creating membranes for hemodialysis (HD) applications is ensuring biocompatibility. Therefore, to maintain the biocompatibility of PSf membranes, further modifications are necessary. Methods: In this study, the performance and biocompatibility of PSf membranes were improved by the impregnation of TiO2‐hydroxyapatite composite as an additive. The TiO2‐hydroxyapatite composite was first synthesized via sintering at 1200°C, and then a dope solution composed of pristine PSf polymer solution in N‐Methyl‐2‐pyrrolidone solvent (NMP) and different wt% ratios of the synthesized composite were prepared, and resultant membranes were fabricated using a film applicator via a phase inversion scheme using water as a non‐solvent exchange medium. The synthesized composite was characterized using SEM, EDX, and XRD techniques. Results: The FTIR analysis confirmed the weak interaction of PSf polymer with the hydroxyapatite moiety of the composite. The interaction of the synthesized composite within the membrane matrix was evaluated via leaching ratio results. The hydrophilicity, pore profile, and pure water permeation flux rates were also determined. The results of the biocompatibility study showed that membranes based on TiO2‐hydroxyapatite composite had reduced adsorption of BSA protein by 34.41% as well as less than 5% hemolysis ratio. Additionally, the study displayed thrombus formation ranging from 2.08% to 8.69%, respectively. The dialysis results indicated that compared with the original PSf membrane, the TiO2‐hydroxyapatite composite showed high clearance rates for urea (73.81%) and creatinine (72.13%) solutes, respectively. Conclusion: Therefore, blending TiO2‐hydroxyapatite composite in the PSf membrane significantly improved the biocompatibility and removal ability of uremic solutes. [ABSTRACT FROM AUTHOR]