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Levofloxacin prophylaxis in pediatric oncology and hematopoietic stem cell transplantation: a literature review.

Authors :
Koo, Jane
Hord, Jeffrey
Gilliam, Craig
Rae, Mary Lynn
Staubach, Katherine
Nowacki, Katherine
Lyren, Anne
Coffey, Maitreya
Dandoy, Christopher E.
Source :
Pediatric Hematology & Oncology. Sep2024, Vol. 41 Issue 6, p432-448. 17p.
Publication Year :
2024

Abstract

Bloodstream infections (BSI) are one of the leading causes of morbidity and mortality in children and young adults receiving chemotherapy for malignancy or undergoing hematopoietic stem cell transplantation (HSCT). Antibiotic prophylaxis is commonly used to decrease the risk of BSI; however, antibiotics carry an inherent risk of complications. The aim of this manuscript is to review levofloxacin prophylaxis in pediatric oncology patients and HSCT recipients. We reviewed published literature on levofloxacin prophylaxis to prevent BSI in pediatric oncology patients and HSCT recipients. Nine manuscripts were identified. The use of levofloxacin is indicated in neutropenic children and young adults receiving intensive chemotherapy for leukemia or undergoing HSCT. These results support the efficacy of levofloxacin in pediatric patients with leukemia receiving intensive chemotherapy and should be considered in pediatric patients undergoing HSCT prior to engraftment. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
08880018
Volume :
41
Issue :
6
Database :
Academic Search Index
Journal :
Pediatric Hematology & Oncology
Publication Type :
Academic Journal
Accession number :
179109001
Full Text :
https://doi.org/10.1080/08880018.2024.2353888