Outpatient Treatment of Confirmed COVID-19: Living, Rapid Practice Points From the American College of Physicians (Version 2, Update Alert).

This document is an update alert from the American College of Physicians (ACP) on the outpatient treatment of confirmed COVID-19 in adults, specifically focusing on the SARS-CoV-2 Omicron variant. The ACP Center for Evidence Reviews identified 9 newly published studies that met the inclusion criteria for the surveillance search. The new evidence supports the use of molnupiravir and nirmatrelvir-ritonavir combination therapy in the outpatient treatment of adults with confirmed COVID-19 at a high risk for severe disease. The document also states that ivermectin and sotrovimab should not be used for the treatment of mild to moderate COVID-19 in the outpatient setting. The Population Health and Medical Science Committee plans to perform a focused update of the evidence review and practice points in light of ongoing studies. [Extracted from the article]