Synergic fabrication of gold – iron oxide magnetic nanohybrids as a potential agent for thermosensitizing and magnetic resonance-high intensity focused ultrasound (mr-HIFU) treatment in uterine myomas.

AbstractThe major aim of this research hyperthermia and magnetic resonance-high intensity focused ultrasound (MR-HIFU) focused on investigating the potential of <italic>aloe vera</italic> leaf extract-mediated gold-coated iron oxide nanohybrids (Au-IONPs) as a modern theragnostic material for the treatment of uterine myoma. To assess the cytotoxicity of Au-IONPs, induce hyperthermia, and apply radiotherapy to determine the level of apoptosis in the human ht-UtLM cells. Subsequently, it evaluated the cytotoxicity of the nanoparticles on human ht-UtLM cells by exposing the cells to various concentrations of Au-IONPs for a 4-hour incubation period. Based on the results, concentrations of 10 and 15 µg/mL were selected for further investigation. The MTT assay and flow cytometry results demonstrated that Au-IONPs significantly induce cell apoptosis. It allows the Au-IONPs to turn as an effective development mediator in the ablation of high-intensity focused ultrasound (HIFU) treatment. Finally, it could be suggested to developed material have excellent systemic toxicity, which promises well for treatment of uterine fibroids.HIGHLIGHTSBiosynthesis of gold – iron oxide nanohybrids (Au-IONPs) through a green approach.Physio-chemical properties of Au-IONPs have been characterized through various techniques.Investigating the anti-tumor effects of Au-IONPs in combination with thermo-radiotherapy for uterine myoma.Determine the level of apoptosis in the human myoma cells by inducing hyperthermia and radiotherapy.Observed the correlation behavior between the dose of the cell viability and Au-IONP nanoparticles.Au-IONPs had a significant impact on enhancing the effects of both hyperthermia and radiation therapies.Biosynthesis of gold – iron oxide nanohybrids (Au-IONPs) through a green approach.Physio-chemical properties of Au-IONPs have been characterized through various techniques.Investigating the anti-tumor effects of Au-IONPs in combination with thermo-radiotherapy for uterine myoma.Determine the level of apoptosis in the human myoma cells by inducing hyperthermia and radiotherapy.Observed the correlation behavior between the dose of the cell viability and Au-IONP nanoparticles.Au-IONPs had a significant impact on enhancing the effects of both hyperthermia and radiation therapies. [ABSTRACT FROM AUTHOR]