Halogenation on 6-β-anhydroicaritin mediated by DBDMH or DCDMH.

Halogenation reaction is often used for structural modification of natural products in drug research. However, no literature was reported for the bromination of acid-sensitive β-anhydroicaritin. We found that DBDMH might act as a mild and effective brominating agent on C-6 of β-anhydroicaritin, and give the desired product in a good yield. This reaction has a wide substrate scope. [Display omitted] • A convenient bromination of β-anhydroicaritin has been successfully developed, which was mediated by DBDMH in good yields. • The mechanism was also investigated and the structure was identified by X-ray spectra. • This protocol provides a feasible method for the bromination on the other phenols natural products. [ABSTRACT FROM AUTHOR]