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Ligand‐Boosted Copper Catalysis for Air‐Tolerant Methoxylation of (Hetero)aryl Halides With Sodium Methoxide.
- Source :
-
Applied Organometallic Chemistry . Aug2024, p1. 9p. 10 Illustrations. - Publication Year :
- 2024
-
Abstract
- ABSTRACT An air‐tolerant, simple yet highly efficient copper‐catalyzed methoxylation of (hetero)aryl bromides and some activated chlorides has been developed by using copper(II) chloride/2,2‐bipyridine as catalyst precursor. A wide range of (hetero)aryl bromides and electron‐deficient chlorides could be efficiently methoxylated in good to excellent yields at 1‐mol% catalyst loading albeit showing a functional group compatibility dependent on the electronic properties of aryl ring. Applications of the practical protocol have been demonstrated in multigram synthesis of 3,4,5‐trimethoxytoluene. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ARYL bromides
*ARYL halides
*COPPER
*FUNCTIONAL groups
*CATALYSIS
*COPPER chlorides
Subjects
Details
- Language :
- English
- ISSN :
- 02682605
- Database :
- Academic Search Index
- Journal :
- Applied Organometallic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 179082112
- Full Text :
- https://doi.org/10.1002/aoc.7708