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Acacia fiber or probiotic supplements to relieve gastrointestinal complaints in patients with constipation-predominant IBS: a 4-week randomized double-blinded placebo-controlled intervention trial.
- Source :
-
European Journal of Nutrition . Aug2024, Vol. 63 Issue 5, p1983-1994. 12p. - Publication Year :
- 2024
-
Abstract
- Purpose: To date, no adequate treatment for irritable bowel syndrome with predominant constipation complaints (IBS-C) is available. Fibers with prebiotic properties and probiotic compounds have shown promise in relieving IBS-C-related complaints. We aimed to determine the effects of a 4-week intervention with either an Acacia fiber (AF) with prebiotic properties or a probiotic Bifidobacterium Lactis (BLa80) supplement, compared to a control supplement, on stool pattern, IBS symptoms and Quality of Life (QoL), in IBS-C individuals. Methods: A parallel, double-blind, randomized controlled trial involving 180 subjects meeting the ROME IV criteria for IBS-C was conducted. Following a 4-week observation period, subjects received either AF (10 g), Probiotic BLa80 (4 g; 2 × 1011 CFU/g) or a maltodextrin placebo (10 g) daily for 4 weeks. Subjects reported daily information on stool pattern and gastrointestinal complaints. Before and after each 4-week period, questionnaires on symptom severity, constipation symptoms, anxiety and depression and QoL were completed. Stool mass was measured for 5-days before and after the intervention. Results: Stool frequency significantly improved in the AF and Probiotic BLa80 groups compared to placebo (P < 0.001, P = 0.02, respectively). Probiotic BLa80 showed a significant reduction in IBS symptom severity (P = 0.03), for AF a trend towards decreased constipation symptoms (PAC-SYM, P = 0.10) was observed. No significant changes in stool consistency, stool mass or QoL measures were observed between the AF and Probiotic BLa80 compared to placebo. Conclusion: Daily dietary supplementation with Acacia fiber and probiotic supplements might help IBS-C patients by relieving IBS-related complaints compared to a placebo supplement. Registration number of clinical trial: The trial is registered at ClinicalTrials.gov: NCT04798417: Study Details | Nutrition to Relieve IBS Constipation | ClinicalTrials.gov. [ABSTRACT FROM AUTHOR]
- Subjects :
- *THERAPEUTIC use of probiotics
*BIFIDOBACTERIUM
*IRRITABLE colon
*PLACEBOS
*RESEARCH funding
*FECES
*STATISTICAL sampling
*BLIND experiment
*QUESTIONNAIRES
*TREATMENT effectiveness
*RANDOMIZED controlled trials
*ANXIETY
*DESCRIPTIVE statistics
*DIETARY fiber
*QUALITY of life
*PROBIOTICS
*COMPARATIVE studies
*DIETARY supplements
*CONSTIPATION
*MENTAL depression
*DISEASE complications
Subjects
Details
- Language :
- English
- ISSN :
- 14366207
- Volume :
- 63
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- European Journal of Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 179069418
- Full Text :
- https://doi.org/10.1007/s00394-024-03398-8