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Association between the third trimester maternal serum metabolome and child growth and development through the first year of life.

Association between the third trimester maternal serum metabolome and child growth and development through the first year of life.

Authors :
da Silva Rosa Freire, Samary
Padilha, Marina
Lima Ferreira, Ana Lorena
Machado Schincaglia, Raquel
Cunha Figueiredo, Amanda Caroline
Freitas-Costa, Nathalia Cristina
Yin, Xiaofei
Brennan, Lorraine
Kac, Gilberto
Source :
Scientific Reports. 8/7/2024, Vol. 14 Issue 1, p1-11. 11p.
Publication Year :
2024

Abstract

Evidence suggests that maternal metabolome may be associated with child health outcomes. We analyzed the association between the maternal metabolome between 28–35 gestational weeks and child growth and development during the first year. A prospective cohort of 98 mother–child dyads was followed at birth, 1, 6, and 12 months. Maternal serum samples were collected for targeted LC–MS/MS analysis, which measured 132 metabolites. The child's growth and development were assessed at each time-point. Z-scores were calculated based on WHO growth standards, and the domains of development were assessed using the Ages and Stages Questionnaires (ASQ-3). Multiple linear mixed-effects models were performed and confounders were identified using a Diagram Acyclic Graph. The Benjamini–Hochberg correction was used for multiple comparison adjustments. We found a positive association between lysophosphatidylcholines (14:0; 16:0; 16:1; 17:0; 18:0; 18:1; 18:2; 20:4) with the z-score of weight-for-age, and lysophosphatidylcholines (14:0; 16:0; 16:1; 18:0) and taurine with the z-score of weight-for-length, and lysophosphatidylcholines (14:0; 16:0; 16:1; 17:0; 18:0; 18:1; 18:2; 20:4) and glycine with the z-score of BMI-for-age. The leucine, methionine, tryptophan, and valine were negatively associated with the fine motor skills domain. We observed an association between maternal metabolome and the growth and child's development throughout the first year. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20452322
Volume :
14
Issue :
1
Database :
Academic Search Index
Journal :
Scientific Reports
Publication Type :
Academic Journal
Accession number :
179055398
Full Text :
https://doi.org/10.1038/s41598-024-69247-0