Automated diffusion‐weighted image analysis along the perivascular space index reveals glymphatic dysfunction in association with brain parenchymal lesions.

Brain glymphatic dysfunction is critical in neurodegenerative processes. While animal studies have provided substantial insights, understandings in humans remains limited. Recent attention has focused on the non‐invasive evaluation of brain glymphatic function. However, its association with brain parenchymal lesions in large‐scale population remains under‐investigated. In this cross‐sectional analysis of 1030 participants (57.14 ± 9.34 years, 37.18% males) from the Shunyi cohort, we developed an automated pipeline to calculate diffusion‐weighted image analysis along the perivascular space (ALPS), with a lower ALPS value indicating worse glymphatic function. The automated ALPS showed high consistency with the manual calculation of this index (ICC = 0.81, 95% CI: 0.662–0.898). We found that those with older age and male sex had lower automated ALPS values (β = −0.051, SE = 0.004, p <.001, per 10 years, and β = −0.036, SE = 0.008, p <.001, respectively). White matter hyperintensity (β = −2.458, SE = 0.175, p <.001) and presence of lacunes (OR = 0.004, 95% CI < 0.002–0.016, p <.001) were significantly correlated with decreased ALPS. The brain parenchymal and hippocampal fractions were significantly associated with decreased ALPS (β = 0.067, SE = 0.007, p <.001 and β = 0.040, SE = 0.014, p =.006, respectively) independent of white matter hyperintensity. Our research implies that the automated ALPS index is potentially a valuable imaging marker for the glymphatic system, deepening our understanding of glymphatic dysfunction. [ABSTRACT FROM AUTHOR]