Evaluation of dermal and ocular safety of natural products based on Murraya paniculata, Eucalyptus sp. and Indigofera suffruticosa Mill. in New Zealand rabbits.

This study was conducted to evaluate the acute dermal and ocular irritant potential of three natural products obtained from medicinal plants Murraya paniculata (PNI), Eucalyptus sp. (PNII), and Indigofera suffruticosa Mill. (PNIII) for topical use in veterinary medicine. For the assessment of acute dermal and ocular irritability, methodologies from the Organization for Economic Cooperation and Development (OECD) were employed through guidelines 404 and 405, respectively, using New Zealand albino rabbits. The evaluated products showed no signs or symptoms of irritation/corrosion on the skin and eyes, exhibiting dermal and ocular irritation indices within the range of classification of non-irritating substances, according to the OECD Harmonized Integrated Classification System. [ABSTRACT FROM AUTHOR]