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Reliable biological and multi-omics research through biometrology.

Authors :
Dong, Lianhua
Zhang, Yu
Fu, Boqiang
Swart, Claudia
Jiang, Huayan
Liu, Yahui
Huggett, Jim
Wielgosz, Robert
Niu, Chunyan
Li, Qianyi
Zhang, Yongzhuo
Park, Sang-Ryoul
Sui, Zhiwei
Yu, Lianchao
Liu, Yangyang
Xie, Qing
Zhang, Hongfu
Yang, Yueyuxiao
Dai, Xinhua
Shi, Leming
Source :
Analytical & Bioanalytical Chemistry. Jul2024, Vol. 416 Issue 16, p3645-3663. 19p.
Publication Year :
2024

Abstract

Metrology is the science of measurement and its applications, whereas biometrology is the science of biological measurement and its applications. Biometrology aims to achieve accuracy and consistency of biological measurements by focusing on the development of metrological traceability, biological reference measurement procedures, and reference materials. Irreproducibility of biological and multi-omics research results from different laboratories, platforms, and analysis methods is hampering the translation of research into clinical uses and can often be attributed to the lack of biologists' attention to the general principles of metrology. In this paper, the progresses of biometrology including metrology on nucleic acid, protein, and cell measurements and its impacts on the improvement of reliability and comparability in biological research are reviewed. Challenges in obtaining more reliable biological and multi-omics measurements due to the lack of primary reference measurement procedures and new standards for biological reference materials faced by biometrology are discussed. In the future, in addition to establishing reliable reference measurement procedures, developing reference materials from single or multiple parameters to multi-omics scale should be emphasized. Thinking in way of biometrology is warranted for facilitating the translation of high-throughput omics research into clinical practices. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
16182642
Volume :
416
Issue :
16
Database :
Academic Search Index
Journal :
Analytical & Bioanalytical Chemistry
Publication Type :
Academic Journal
Accession number :
178995528
Full Text :
https://doi.org/10.1007/s00216-024-05239-3