Actinic keratosis: An update on management.

Actinic keratosis (AK) is a skin condition caused by chronic UV radiation damage and is a precursor to keratinocyte cancer. Treatment options for AK include cryotherapy, topical 5-fluorouracil (5-FU), imiquimod, photodynamic therapy (PDT), diclofenac, and tirbanibulin. Cryotherapy is recommended for targeted treatment, while 5-FU and imiquimod are recommended for broader treatment. PDT uses a topical photosensitizer and light activation, while diclofenac and tirbanibulin are also effective treatments. Caution is advised when using novel medications like tirbanibulin until more long-term trial data is available. Ingenol mebutate gel, previously used for AK treatment, has been withdrawn from the market due to an increased risk of non-melanocytic skin cancer. Sun protection and regular skin checks are important for immunosuppressed patients. [Extracted from the article]