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The role and therapeutic strategies for tissue‐resident memory T cells, central memory T cells, and effector memory T cells in psoriasis.
- Source :
-
Immunology . Aug2024, p1. 11p. 2 Illustrations. - Publication Year :
- 2024
-
Abstract
- Psoriasis is a skin disease that is inflammatory and persistent, causing a high rate of recurrence, poor quality of life, and significant socioeconomic burden. Its main pathological manifestations are abnormal activation and infiltration of T cells and excessive proliferation of keratinocytes (KCs). The great majority of patients with psoriasis will relapse after remission. It usually lasts a lifetime and necessitates long‐term treatment strategies. During periods of activity and remission, one of the main cell types in psoriasis is memory T cells, which include tissue‐resident memory T (TRM) cells, central memory T (TCM) cells, and effector memory T (TEM) cells. They work by releasing inflammatory factors, cytotoxic particles, or altering cell subpopulations, leading to increased inflammation or recurrence. This review summarizes the role of memory T cells in the pathology and treatment of psoriasis, with a view to potential novel therapies and therapeutic targets. [ABSTRACT FROM AUTHOR]
- Subjects :
- *IMMUNOLOGIC memory
*T cells
*SKIN diseases
*DRUG target
*PSORIASIS
Subjects
Details
- Language :
- English
- ISSN :
- 00192805
- Database :
- Academic Search Index
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 178966465
- Full Text :
- https://doi.org/10.1111/imm.13843