Structural Cardiac Interventions in Patients With Heart Failure: JACC Scientific Statement.

Pathologic left ventricular remodeling and valvular heart disease may contribute to the clinical presentation and outcomes of patients presenting with heart failure, and limit the effectiveness of guideline-directed medical therapy. Although surgical interventions including surgical ventricular restoration techniques and valve repair or replacement are effective therapies, there is growing evidence that transcatheter interventions may be options for patients with persistent symptoms of heart failure despite optimal medical therapy, where surgical options may be limited. This scientific statement will review the current available and investigational percutaneous strategies for the management of structural contributors to heart failure: dilated left ventricular cardiomyopathies and valvular heart disease. • Structural cardiac abnormalities limit the effectiveness of GDMT for HF. • Transcatheter interventions to address structural abnormalities are potential alternatives to high-risk surgery in patients with HF. • Better data are needed to confirm the safety and efficacy of transcatheter treatment of refractory HF. [ABSTRACT FROM AUTHOR]