Inhibiting the cancer cell growth by maleopimarate amino imide bis-tetrazoles synthesized via the azido-Ugi reaction.

[Display omitted] The azido-Ugi reaction of methyl maleopimarate N -(2- aminoethyl) imide with isocyanides, paraformaldehyde and trimethylsilyl azide in one step leads to 1,5-disubstituted diterpene bis-tetrazoles. The compounds demonstrate selective cytotoxicity against NCI-60 cancer cell panel. [ABSTRACT FROM AUTHOR]