Hot technology and technical evolution of polypeptide nanotechnology in medical application field based on patent data analysis.

The design of nanostructures based on peptides has attracted wide attention, especially the design of new nanomaterials with higher levels of multifunctional ability is gradually needed. Patent layout allows to identification of related technologies and trends. To reveal the development of global polypeptide nanotechnology in the field of medical application, this paper uses the text mining technology based on patent semantic content to extract the contained knowledge from the patent data set from 1978 to 2023 retrieved from incoPat database and combines the knowledge network with the theme evolution. The hot topics were obtained, and the main technical topics of improving the function of nanomaterials modified by polypeptide were analyzed: the nanointelligent delivery system modified by polypeptide improved the response to stimuli, the transfection rate of gene therapy was improved, the targeting and cell penetration of tumor therapy were improved, the diagnostic sensitivity and biocompatibility were improved, and the detection time of sensors was improved. The research shows that most nanotechnology based on polypeptide is used in medicine to optimize the effect of chemotherapy for tumor treatment. The development of gene therapy is developing rapidly, and technologies such as diagnosis and sensors are emerging, which seems to be very promising. They may hide great potential and represent the field of opportunity research. Most importantly, the technologies related to polypeptide-modified nanostructures are still rapidly developing, and this trend is expected to continue in the next few years. [ABSTRACT FROM AUTHOR]