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The functional roles of S‐adenosyl‐methionine and S‐adenosyl‐homocysteine and their involvement in trisomy 21.

Authors :
Caracausi, Maria
Ramacieri, Giuseppe
Catapano, Francesca
Cicilloni, Michela
Lajin, Bassam
Pelleri, Maria Chiara
Piovesan, Allison
Vitale, Lorenza
Locatelli, Chiara
Pirazzoli, Gian Luca
Strippoli, Pierluigi
Antonaros, Francesca
Vione, Beatrice
Source :
Biofactors. Jul2024, Vol. 50 Issue 4, p709-724. 16p.
Publication Year :
2024

Abstract

The one‐carbon metabolism pathway is involved in critical human cellular functions such as cell proliferation, mitochondrial respiration, and epigenetic regulation. In the homocysteine‐methionine cycle S‐adenosyl‐methionine (SAM) and S‐adenosyl‐homocysteine (SAH) are synthetized, and their levels are finely regulated to ensure proper functioning of key enzymes which control cellular growth and differentiation. Here we review the main biological mechanisms involving SAM and SAH and the known related human diseases. It was recently demonstrated that SAM and SAH levels are altered in plasma of subjects with trisomy 21 (T21) but how this metabolic dysregulation influences the clinical manifestation of T21 phenotype has not been previously described. This review aims at providing an overview of the biological mechanisms which are altered in response to changes in the levels of SAM and SAH observed in DS. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09516433
Volume :
50
Issue :
4
Database :
Academic Search Index
Journal :
Biofactors
Publication Type :
Academic Journal
Accession number :
178910259
Full Text :
https://doi.org/10.1002/biof.2044