Evaluating the anticancer potential of Polygonum multiflorum root-derived stilbenes against H2452 malignant pleural mesothelioma cells.

A naturally occurring stilbene, resveratrol, shows promising effects in the treatment of malignant pleural mesothelioma (MPM) both as a single agent and in combination with chemotherapeutic drugs. To discover new anticancer agents targeting MPM, stilbene-targeted isolation was performed on the roots of Polygonum multiflorum Thunb., an herbal medicine rich in stilbene compounds. In this study, seven stilbene glycosides (1 – 7) were isolated, along with four non-stilbenes (8 – 11), of which compounds 4 and 9 – 11 have not previously been isolated from this species. Stiquinoside A (1) is a previously undescribed stilbene glycoside, and its structure was elucidated as (E)-2,3,5,4′-tetrahydroxystilbene 2- O - β - d -quinovopyranoside based on 1D and 2D-NMR, HR-ESI-MS, and acid hydrolysis experiments. Compounds 1 , 4 , 6 , and 8 significantly inhibit the growth of MPM cancer cells H2452. These results demonstrate the potential utility of stilbenes in new strategies for the treatment of MPM. [Display omitted] • A new (1) and six reported (2 – 7) stilbenes were obtained from Polygonum multiflorum. • Three non-stilbenes (9 – 11) were isolated from P. multiflorum for the first time. • Stilbenes 1 , 4 , and 6 showed significant inhibitory effects on H2452 cells. • Emodin (8), an anthraquinone, significantly inhibited H2452 cells. [ABSTRACT FROM AUTHOR]