The genus Litsea: A comprehensive review of traditional uses, phytochemistry, pharmacological activities and other studies.

Ethnopharmacological relevance :The genus L. has high medicinal value and has traditional been used to treat a variety of gastrointestinal disorders, as well as diabetes, edema, colds, arthritis, asthma, and traumatic injuries. Aim of the review : This work addresses the missing information by conducting a comprehensive analysis of the traditional uses, chemical components, and pharmacological applications of the more reported species of the genus L. The origin of the genus, its toxicology, and the use of classical therapies in modern medicine were also discussed. It provides references for historical evidence, resource development, and medical research on the genus. ology : Data about the genus L. were gathered via Web of Science, PubMed, Science Direct, Google Scholar, Connected Papers, China National Knowledge Infrastructure (CNKI), electronic ancient books and local chronicles. The WFO Plant List (wfoplantlist.org) and Flora of China (www.iplant.cn) confirmed L.'s Latin name, and the species information. The program ChemBioDraw Ultra 14.0 was used to create the molecular structures of the compounds that were displayed in the text. Currently, at least 740 constituents have been isolated and identified from L. These include 9 groups of chemicals, such as flavonoids, alkaloids, and terpenoids. They have been shown to have over 20 biological properties in vivo and in vitro , such as antibacterial, anti-inflammatory, and anti-oxidant effects. Based on pharmacological investigations, chemical components, and traditional folk applications, L. is considered a medicinal plant having a variety of pharmacological actions. However, although the pharmacological activity of the L. genus has been preliminary demonstrated, most have only been assessed using simple in vitro cell lines or animal disease models. In order to fully elucidate the pharmacological activity and mechanisms of L., future studies should be conducted in a more comprehensive clinical manner. [Display omitted] • A textual study of the origin of Litsea and the main species (L. cubeba) was carried out. • Summarizes the traditional uses of Litsea in different countries. • 740 chemical constituents of the genus Litsea were summarised. • Over 20 pharmacological applications of the genus Litsea are summarised. • The genus Litsea's classical prescriptions play an important role in modern pharmacology. [ABSTRACT FROM AUTHOR]