SATB2‐rearrangement in a case of juvenile trabecular ossifying fibroma, expanding the spectrum of SATB2‐rearranged neoplasia.

This article discusses a case study of a rare tumor called juvenile trabecular ossifying fibroma (JTOF). The study found that JTOF can have similar genetic alterations to another type of tumor called psammomatoid ossifying fibroma (PsOF), specifically rearrangements in the SATB2 gene. The patient in the case study was a 12-year-old girl who had a rapidly growing mandibular lesion. The tumor was surgically removed, and genetic analysis revealed SATB2 gene rearrangements. This expands our understanding of the molecular landscape of JTOF and suggests that SATB2 anomalies may play a role in the development of these tumors. Further research is needed to fully understand the genetic factors involved in JTOF. [Extracted from the article]